Denne detaljstyringen fortsetter selv etter den første godkjenningen, og hvert enkelt tilfelle krever individuell validering fra Statens legemiddelverk.De økende kostnadene har fileått stadig flere nordmenn til å søke behandling utenfor landets grenser, noe som viser hvordan overdreven regulering og sentralisert kontroll til syvende og sist sk
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